qq_42189072的博客

在学习Linux的过程中，经常会听到Shell这个词。可能大家在使用Windows的时候有这种感觉，我要听歌 ，我打开一个播放器，那么音箱就可以出声音，要打印一片文档，我们只要在程序中点击一下打印按钮，打印 就会自动的把文档打印出来。但是我们并没有自己手动的控制音箱和打印机等硬件设备，是因为系统已经为我 们作好了。其实我们可以把Windows叫做Shell，我们不用知道打印机的原理，也不需要自己控制它，我们只需 要轻轻的点击一下鼠标，系统为我们来控制这些硬件设备。

MECAT is an ultra-fast Mapping, Error Correction and de novo Assembly Tools for single molecula sequencing (SMRT) reads. MECAT employs novel alignment and error correction algorithms that are much more efficient than the state of art of aligners and error correction tools. MECAT can be used for effectively de novo assemblying large genomes. For example, on a 32-thread computer with 2.0 GHz CPU , MECAT takes 9.5 days to assemble a human genome based on 54x SMRT data, which is 40 times faster than the current PBcR-Mhap pipeline. We also use MECAT to assemble a diploid human genome based on 102x SMRT data only in 25 days. The latter assembly leads a great improvement of quality to the previous genome assembled from the 54x haploid SMRT data. MECAT performance were compared with PBcR-Mhap pipeline, FALCON and Canu(v1.3) in five real datasets. The quality of assembled contigs produced by MECAT is the same or better than that of the PBcR-Mhap pipeline and FALCON. Here are some comparisons on the 32-thread computer with 2.0 GHz CPU and 512 GB RAM memory:

生物信息库是国家基因库的一个分支，是一个开放性、公益性平台。生物信息库围绕“大数据”为中心，依托国家基因库样本库丰富的生物样本资源及深圳华大基因研究院高通量测序平台、高性能计算平台和信息分析能力，收集海量的基因组、转录组、蛋白组、代谢组及临床表型等数据信息，并致力于搭建生物大数据共享和应用平台。